Breast cancer–specific mortality increases in patients with contralateral breast cancer (CBC) diagnosed before the age of 70 . A population-based analysis showed the overall risk for CBC in 10 to 15 years after primary diagnosis was 4.4%; in another study, the 10-year cumulative risk for CBC was 9.8% and 23.8% for BRCA1/2 carriers and non-carriers, respectively ( 5 , 6 ).
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A contralateral breast cancer is a new cancer that occurs in the breast opposite to the one you already had breast cancer in. A contralateral breast cancer is not considered a recurring cancer. A breast cancer recurrence happens when the same cancer comes back in the same breast (local recurrence) or in nearby lymph nodes (regional recurrence). In a multivariable analysis, controlling for age at diagnosis, year of diagnosis, treatment, and other prognostic features, contralateral mastectomy was associated with a 48% reduction in death from breast cancer (hazard ratio 0.52, 95% confidence interval 0.29 to 0.93; P=0.03).
Therefore, some women with DCIS choose contralateral prophylactic mastectomy to prevent a future breast cancer in the contralateral breast despite a lack of a proven survival benefit. Alternatively, women who have undergone unilateral mastectomy for DCIS may elect endocrine therapy as chemoprevention against a future primary breast cancer in the contralateral breast.
Young age at first primary breast cancer diagnosis is associated with an increased contralateral breast cancer risk, poor prognosis and serves as an independent predictor of recurrence and breast-cancer-related death [66,67,68,69,70,71] . 2019-05-07 2020-01-11 2016-11-29 RESEARCH ARTICLE Expression of HIF-1α is related to a poor prognosis and tamoxifen resistance in contralateral breast cancer Annika Jo¨ gi ID 1*, Anna Ehinger2,3, Linda Hartman2, Sara Alkner2 1 Further, both simultaneously occurring (synchronous) contralateral breast cancer and non-simultaneous (metachronous) contralateral breast cancer have a worse prognosis than breast cancer in general. The population-based cohort used in all four studies includes all patients diagnosed with contralateral breast cancer in the Stockholm region during 1976-2005 (N=1422).
1 Apr 2013 003) were associated with risk of contralateral cancer diagnosis in multivariate analysis. Conclusion. A single MR imaging screening examination
The 17 Nov 2015 Our data have identified BCs associated with a very low recurrence risk 5 to 10 years after diagnosis, providing women with such cancers 24 Nov 2015 of breast cancer many years after its initial diagnosis and treatment. breast or in the other breast (contralateral), it is usually a new tumor. 19 Mar 1992 Fewer than 3 percent of all second breast cancers in this study could be attributed to previous radiation treatment; the risk, however, was 1 Apr 2013 003) were associated with risk of contralateral cancer diagnosis in multivariate analysis. Conclusion. A single MR imaging screening examination 6 Oct 2019 “These findings may support clinical decision making related to radiation treatment, particularly among women for whom other modalities may be one breast cancer are known to be at high risk for contralateral disease, follow-up Prognosis in bilateral breast cancer: effects of time interval between first and Contralateral breast cancer is today treated as a new primary tumor. The impact of the biological relationship between the first and second breast cancer, as well BACKGROUND: Although 2-20% of breast cancer patients develop a contralateral breast cancer (CBC), prognosis after CBC is still debated. Using a unique av MEC Sandberg · 2012 · Citerat av 1 — Contralateral Breast Cancer.
The annual average risks of ipsilateral breast cancer in the three groups were 2.7%, 1.4%, and 1.1%, respectively (P = 0.06).
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The annual average risks of ipsilateral breast cancer in the three groups were 2.7%, 1.4%, and 1.1%, respectively (P = 0.06). BRCA1 pathogenic variant carriers had significantly higher risks of contralateral (hazard ratio 1.91, P < 0.001) and ipsilateral (hazard ratio 2.00, P = 0.02) breast cancers than non-BRCA1/2 pathogenic variant carriers. The absolute number of breast cancer survivors who are at risk for metachronous contralateral breast cancer (mCBC) has dramatically increased.
PATIENTS AND METHODS: In 45,229 surgically treated stage I-IIIA patients diagnosed in the Netherlands between 1989 and 2002 CBC risk was quantified using standardised incidence ratios (SIRs), cumulative incidence and Cox regression analysis, adjusted for …
Breast cancer survivors are at risk for contralateral breast cancer (CBC), with the consequent burden of further treatment and potentially less favorable prognosis.
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Prostate cancer is a common type of cancer in men, according to the Mayo Clinic. It may grow slowly and it's typically treatable. But hearing the words can still be scary. Here are 10 more facts about prostate cancer.
2012-08-27 · With the use of a hospital database of women recruited from 1970 to 2006, we showed that the risk of developing CBC and prognosis after CBC are associated with the advanced stage of the primary tumor 10,11 and that a short interval time between the primary breast cancer and CBC considerably worsens the prognosis 11 compared with women with unilateral breast cancer (UBC). Not surprisingly, the prognosis is worse for contralateral breast cancer occurring within two years of the original tumor.
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Prognosis, stage and oestrogen receptor status of contralateral breast cancer in relation to characteristics of the first tumour, prior endocrine
International development of arm lymphedema following breast cancer treatment: A match Weingrad DN, Davey S. Local tissue water in at-risk and contralateral forearms. breast cancer syndrome, risk assessment, risk model logic and molecular risk factors for contralateral 99m sestamibi in the diagnosis of breast cancer. The. The treatment of breast cancer is, according to the guide- lines, multidisciplinary. risk and prognosis of contralateral breast cancer: Results from a large av H Eerola — mutationer leder till en stor risk för bröst- och ovariecancer samt eventuellt också för flera centra (Breast Cancer Linkage Consor- milial and hereditary factors on the prognosis of breast can- cer. Tamoxifen and risk of contralateral breast. Predicting Prognosis and Tamoxifen Response in Breast Cancer.